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doi: 10.3389/fendo.2023.1070264 86 HuMZhangYMaSLiJWangXLiangMet al

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Mechanistically, PDHA1 increases intracellular acetyl-CoA, enhancing histone H3K27 acetylation and upregulating solute carrier family 7 member 11 (SLC7A11), which promotes cysteine uptake and glutathione (GSH) synthesis